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A Simple Step Before Biopsy

What is the Exo mdx test?

Exo mdx is a simple, non-invasive urine test to assess your risk of having clinically significant or high-grade prostate cancer. The Exo mdx test does not require a digital rectal exam (DRE) and provides an individualized risk score that can help determine whether to proceed or defer a prostate biopsy. Exo mdx is available for at-home collection.

Are You:

  • A man aged 50 or older?
  • Have a prostate-specific antigen (PSA) level between 2 and 10 ng/mL?
  • Speaking with your doctor or concerned about an initial or repeat prostate biopsy?
  • Interested in a TeleHealth solution through the At-Home Collection Kit?


If yes, Exo mdx may be right for you.

Benefits of Choosing Exo mdx

The Exo mdx Test provides a risk assessment for finding clinically significant prostate cancer that otherwise relies on biopsy in men with an elevated PSA. The test provides a simple, painless, and accurate answer to inform the prostate biopsy decision. If the test result indicates that a “low risk”, then the patient and his doctor (using all other clinical information including family history, prior PSA, abnormal DRE) may decide to defer prostate biopsy – avoiding the pain, complications and costs associated with a prostate biopsy.

Confidence and Peace of Mind

Exo mdx can help inform the physician-patient prostate biopsy decision:

  • Non-invasive, simple urine collection, can occur at any time of day 
  • At-Home Collection Kit can be ordered by your physician and sent directly to your home
  • Offers a risk score that informs the prostate biopsy decision 
  • Clinically proven in men age 50 or over, with PSA levels 2-10ng/mL, and considering an initial or repeat prostate biopsy 
  • Included in the 2019 National Comprehensive Cancer Center Network Guidelines (NCCN)

The Exo mdx test is a simple, non-invasive urine test that provides valuable information for the biopsy decision

Exo mdx works by analyzing prostate cancer-specific genomic biomarkers that are highly expressed during tumor cell growth found in the urine. These biomarkers are measured in a clinical laboratory and a validated algorithm calculates a score to determine a man’s risk of having aggressive or clinically significant prostate cancer.

If your Exo mdx score is < 15.6 this means lower risk prostate cancer on biopsy, or benign

The intervention is: Potentially avoid biopsy, continued monitoring

If your Exo mdx score is > 15.6 this means higher risk of high-grade prostate cancer on biopsy

The Intervention is: Potentially proceed to biopsy or MRI

Should I Get The Exo mdx Test?

If you are a man over the age of 50 with a prostate specific antigen (PSA) of 2-10 ng/mL and are considering a prostate biopsy, then you should talk to your doctor or health care provider about Exo mdx. 

The Exo mdx test helps physicians and patients make critical decisions about whether or not to proceed to or defer prostate biopsy. 

  • Simple, non-invasive urine test
  • Included in the May 2019 NCCN guidelines 
  • Granted Breakthrough Designation by the FDA 
  • Covered by Medicare 
  • Performed in more than 70,000 men 
  • Proven to avoid almost 30% of biopsies 

Common Reasons for a Prostate Biopsy

A prostate biopsy is used to diagnose prostate cancer. Your doctor may recommend a prostate biopsy if any of these prostate cancer symptoms are present: 

  • Family history of prostate cancer 
  • Elevated or high PSA 
  • Increasing PSA over time 
  • Abnormal results from a digital rectal exam (DRE) 


The Exo mdx test is a simple urine test that can inform if prostate biopsy is right for you.  

Know Before You Go

Below are some questions you can ask your physician to determine if the Exo mdx test is right for you. 

  1. How is prostate cancer detected?
  2. What is my PSA level and history of PSA levels?
  3. How accurate is the PSA in assessing my risk for high-grade prostate cancer?
  4. What is the chance of having a negative or undetermined result for prostate cancer if I have a prostate biopsy?
  5. What is the chance of having a positive result for prostate cancer if I have a prostate biopsy?
  6. What is the treatment plan if my prostate biopsy results in a “Low Grade” prostate cancer (Grade Group 1 or below)
  7. What are alternatives to a prostate biopsy for diagnosis of prostate cancer?
  8. Is there any risk to taking the Exo mdx test before the biopsy?
  9. Am I a candidate for the Exo mdx Prostate test?
  10. Will I be able to use the At-Home Collection Kit?

Available to Veterans

The Exo mdx test is covered under the General Services Administration (GSA) award contract with mdxhealth. Exo mdx is available to all veterans and many government entities including the VA Healthcare System, military branches such as Army, Navy, Air Force and Marines, as well as the U.S. Senate, House of Representatives, and other legislative bodies.  

The Community Care Network (CCN) on behalf of the Veterans Affairs Department provides health care for Veterans from providers in the local community. The available sites in the CCN are continually growing, ask your doctor today for more information.